Protein Oxidation And Aging

Twenty years ago, it was considered a well-established observation that oxidized proteins, mensurable as protein carbonylics apply 2,4-dinitrophenylhydrazine (DNPH), accumulate during aging (1). The age-related increase in protein carbonyl content was report in human zeal (2), gerbil brain (3), rat liver (4), and flies (5-7). Protein carbonyl content in mouse brain was found to be correlated with age-related decrease of cognitive and motor performance (8). Those report increase of oxidized proteins during aging received no burgeon forth exception until Cao and Cutler published their results (9, 10). They showed that the protein carbonyls could not be reliably measured in normal crude tissue extracts by using the DNPH manner (9). Now, the history seems to stand with their detrimental results because it is quite hard to regain solid data published in this one C and reinforcement the age-related accumulation of protein carbonyls. In addition, protein carbonyls in rat bl ood line did not change with the oxidative stress in the countrywide Biomarkers of aerophilic Stress Study using acute CCl4 toxic condition as a model (11). Protein oxidation and aging or the superior free radical theory of aging is and so bowl a wide-open area waiting for novel and bare-ass technologies to make real advances.

At the same time, scientific journals imply to change their general practice of not print negative findings. Reference 1. E. R. Stadtman, Science 257, 1220 (1992). 2. C. D. Smith et al., Proc. Natl Acad. Sci. regular troops 88, 10540 (1991). 3. J. M. Carney et al., Proc. N atl Acad. Sci. the States 88, 3633 (1991). ! 4. L. D. Youngman, K. J. Park, Proc. Natl Acad. Sci. USA 89, 9112 (1992). 5. R. S. Sohal et al., Proc. Natl Acad. Sci. USA 90, 7255 (1993). 6. W. C. Orr and R. S. Sohal, Science 263, 1128 (1994). 7. L. Yan, R. L. Levine, R. S. Sohal, Proc. Natl Acad. Sci. USA 94, 11168 (1997). 8. M. J. Forster et al., Proc. Natl Acad. Sci. USA 93, 4765 (1996). 9. G. Cao and R. G. Cutler, Arch. Biochem....If you want to get a full essay, order it on our website: OrderCustomPaper.com

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